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Troubling news in Nature :
– The potential danger of suboptimal antibody responses in COVID-19
– There is a desperate need for effective therapies and vaccines for SARS-CoV-2 to mitigate the growing economic crisis that has ensued from societal lockdown. Vaccines are being developed at an unprecedented speed and are already in clinical trials, without preclinical testing for safety and efficacy. Yet, safety evaluation of candidate vaccines must not be overlooked.
– Recent studies of antibody responses in patients with COVID-19 have associated higher titres of anti-N IgM and IgG at all time points following the onset of symptoms with a worse disease outcome. Moreover, higher titres of anti-S and anti-N IgG and IgM correlate with worse clinical readouts and older age, suggesting potentially detrimental effects of antibodies in some patients.