Michael norton:
* – “…this is going to run and run, we will be encouraged to have booster each year, for years to come.”
Probably six-monthly; that seems to be about how long these vaccines protect for.
What I hope is that a more transmissible but considerably less serious strain emerges, becomes dominant through being more transmissible, and it then settles down into being an occasional malady like colds, imparting temporary immunity to whoever catches it.
But because it exploits cells via their ACE2 receptors which so many different tissue types have, possibly all variants of it will be serious. Unlike a cold it can cause very varied long term effects; different symptoms in different people, so even if some of a variant’s effects became less serious, others would probably remain or even get worse.